ChemICare’s research is focused on a specific cellular event, the Store Operated Calcium Entry (SOCE), also known as capacitative calcium entry. This is a specialized form of calcium influx that involves a close communication between the plasma membrane and the endoplasmic reticulum. In particular, in SOCE, the depletion of calcium from the endoplasmic reticulum triggers calcium influx across the plasma membrane.
The SOCE machinery is made up of mainly two proteins, STIM ad ORAI. STIM is located in the endoplasmic reticulum and acts as a calcium sensor, while ORAI is better known as CRAC channel, is an ion channel selective for Ca2+ and mediates the current known as ICRAC. SOCE is involved in many different pathologies and dysfunctions, ranging from cancer to autoimmune, immunological, neuromuscular, cardiovascular, metabolic and genetic disorders. Therefore, it is currently an emerging topic in pharmacology and in medicinal chemistry. In this context, ChemICare is specifically committed to the discovery and the development of modulators of this cellular event that would be clinically useful in the treatment of a cluster of rare genetic diseases and acute pancreatitis paving the way to a cure in the future.